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This results in transient attenuation of global translation.
Second, attenuation of global protein translation to reduce the load of newly synthesized proteins and prevent excessive accumulation of unfolded proteins [15], [16].
Generally, ER stress promotes cell survival through the attenuation of global protein synthesis and the acceleration of protein folding.
Repression of Tet1 and Tet2 provoked a great attenuation of global 5-hmC levels when compared with cells treated only with DMSO (Fig. 9E).
Indeed, eIF2 α phosphorylation is the first-line response to ER stress and allows the immediate attenuation of global protein synthesis and selective translation of stress-responsive genes, which confers the ability to rapidly respond to changes in extracellular environments.
In brief, UPR contains two systems involved in the attenuation of global translation to stop the influx of proteins into the ER and increasing the transcription of chaperones to refold the unfolded proteins in the ER again.
Similar(53)
The two strategies are compared based on the level of attenuation of the global error sound power, the attenuation per total control force, and attenuation per actuator (in a structural-acoustic situation).
The achieved level of attenuation is also compared to the maximum level of attenuation of the global error that can be achieved based on the disturbance/secondary source arrangement.
Simulations are completed to illustrate the validity of the novel approach by illustrating that a controller minimizing the generalized orthogonal functions will achieve the maximum possible attenuation of the global error.
This work examines the active attenuation of the global error, sound power, from the point of view of two sensing/control strategies that seek to be generalised; thus are applicable to a wide range of applications and are independent of knowledge of structural dynamics.
Experimental and theoretical results show that large attenuation at the error microphone is possible along with global attenuation of the acoustic field.
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