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The positive control G5 Supplement contains a mixture of growth factors and compounds and thus while it can stimulate cell growth and activity in vitro, the inclusion of growth factors may also lead to attenuation of effect over time.
While this attenuation of effect may be due to statin therapy alone, it is more likely confounded by other improvements in medical management and patient demographics in these later trials which included lipid-lowering therapy.
The estimates are based on the age group 55 69, with some attenuation of effect with increasing age that will affect all screening strategies similarly.
There was attenuation of effect estimates in the Non-Metro Urban and Rural county classifications.
While publication bias typically results in an attenuation of effect estimates for safety endpoints, resultant bias is not measureable.
Even so, it is possible that some attenuation of effect of biologic therapy might have occurred because of our methods.
Similar(29)
In our analyses, we have not observed an attenuation of effects by including dust-storm days.
The greatest attenuation of effects was seen on adjustment of 'prior educational attainment' and 'child behaviour' models.
This estimation of effects based on baseline rather than time-varying data, which were not available, might have resulted in the attenuation of effects.
For what is possible to see from our analysis, despite this attenuation of effects, the present differences would remain significant in most domains.
The results suggest that exposure misclassification, which can lead to attenuation of effects, may be greater when using ambient data than when using school-based pollutant metrics.
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