Sentence examples for attenuation of disease from inspiring English sources

Of many PA14 mutants tested, only mutation of the quorum sensing regulator LasR showed an attenuation of disease symptoms.

In atherosclerotic coronary arteries, IL-1β levels have been shown to correlate with disease severity [3], and knocking out IL-1β in atherosclerosis-prone ApoE−/− mice leads to attenuation of disease development [4].

However, by specifically targeting the nasal mucosa, the site of initial EHV-1 invasion and replication, this model of attenuation of disease in mice may be predictive for the horse.

In our study, treatment of mice with cis-UCA resulted in attenuation of disease severity, as evidenced by reduced disease activity score, weight loss and maintenance of colonic weight/length ratio.

These values, combined with the weight change score, resulted in a significant attenuation of disease score in the mice treated with cis-UCA at the high dose of 50 µg (Fig. 1B).

We have suggested that these defective genomes impose a fitness burden on the DENV populations in which they are found that may result in attenuation of disease severity, allowing greater mobility of infected human hosts and therefore greater dissemination of virus [18], [19].

Simple error models imply that in epidemiological analyses, purely random reporting errors in exposure data cause attenuation of disease-exposure estimates, according to the ratio of the standard deviation of the errors to the standard deviation of the true values [ 33, 34], so we interpreted the limits of agreement on the scale of the standard deviations of the NSHD values.

The success of neutralization of cytokines in RA and related diseases is documented by the objective attenuation of the disease process as well as by the subjective experience of the patient.

Moreover, inhibition of STAT3 phosphorylation by the JAK2 inhibitor WP1066 led to a marked attenuation of skin disease, demonstrating the relevance of this pathway for the development of clinical disease, further demonstrating the overlap in pathogenesis between psoriasis and the current model (figure 6c).

Features of Strongyloides colitis that contrast with those of ulcerative colitis include (1) skip pattern of the inflammation, (2) distal attenuation of the disease, (3) eosinophil-rich infiltrates, (4) relative intact crypt architecture, and (5) frequent involvement of submucosa.

Attenuation of the disease state could also occur by the protective effect PBA would extend to newly differentiated enterocytes in the intestinal epithelium of an infected individual.