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The combination of multiple attenuation approaches offers the potential to engineer efficiently attenuated Plasmodium parasites and learn about their fascinating biology at the same time.
As we did in the case of the tidal flat, we compare the vegetation distribution resulting from the bathtub and the full attenuation approaches when applied to the 2004 conditions.
The biodegradation of organic contaminants in the subsurface has become a major focus of attention, in part, due to the tremendous interest in applying in situ biodegradation and natural attenuation approaches for site remediation.
Subsurface contamination by organic chemicals is a pervasive environmental problem, susceptible to remediation by natural or enhanced attenuation approaches or more highly engineered methods such as pump-and-treat, amongst others.
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The comparison of model results for current wetland conditions with observations (Fig. 2c) shows that the full attenuation approach (Fig. 2i) captures the general vegetation distribution of the site, whereas the bathtub approach (Fig. 2f) grossly over-predicts mangrove cover.
The implementation of the hydrodynamic model for the full attenuation approach required discretization of the domain into a dense grid (10 × 10 m cells), delimitation of creeks and tidal flats and inclusion/set-up of 10 control structures.
Our findings suggest that the IRES-based attenuation approach can be used to develop a safe and effective vaccine against EEE and other alphaviral diseases.
Together, our data suggest that G7M is a promising genotype VII vaccine candidate, and the novel attenuation approach designed in this study could be used to develop new antigen-matched NDV vaccines.
We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent attenuation approach exemplified by TC-83; a rationally designed, targeted-mutation approach represented by V3526; and a chimeric vaccine, SIN/TC/ZPC.
At the Pulau Sikuai station site, the attenuation approach gave a two times or greater difference in PGA when compared with the measured values for the Mw 7.9 aftershock and Mw 8.5 mainshock respectively.
The present vaccination strategies are contemplating subunit vaccine as an alternative to traditional attenuation approach.
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