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We also demonstrated that AMD3100 decreases the level of several OA-related factors in our animal model, attenuating the severity of primary OA.
Pretreatment with PE extract demonstrated clearly its renoprotetctive effect by attenuating the severity of renal pathological damage and improving renal function with the dose dependent renoprotective effect of PE extract.
A key element in these policies has been the importance of attenuating the severity of chronic health conditions prior to pregnancy to minimise the risk of obstetric and postnatal health problems.
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In the current study, although severe hypercapnic acidosis (PaCO2 at 130-150 mmHg) attenuated the severity of VILI, with prolonged ventilation until the end of the protocol, the oxygenation and histopathologic changes were progressively worse compared with moderate hypercapnic acidosis (PaCO2 at 80-100 mmHg).
2 The progress in understanding the pathophysiology of the majority of these disorders has led to the discovery of several new therapies that have made it possible to attenuate the severity of the clinical manifestations associated with many IEM.
Afelimomab is safe, biologically active, and well tolerated in patients with severe sepsis, reduces 28-day all-cause mortality, and attenuates the severity of organ dysfunction in patients with elevated interleukin-6 levels.
Norharman and LSL 60101 also attenuated the severity of the withdrawal syndrome.
Therapies targeting this pulmonary coagulopathy may also have an anti-inflammatory effect and attenuate the severity of ARDS [50].
Results: In MCT-induced PAH rats, CAPE significantly improved the hemodynamic values of RVSP, Fulton index, and attenuated the severity of pulmonary vascular remodeling.
Introduction of a biodegradable linker between the phosphatidylcholine and detergent moieties significantly attenuates the severity of inflammatory response that characterizes cationic lipid-mediated gene transfer.
Regardless of the treatment regimen, chrysin attenuated the severity and duration of the clinical course of EAN and reduced inflammatory cell infiltration and demyelination of sciatic nerves.
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