Sentence examples for attenuating the function from inspiring English sources

Talebizadeh et al. [63] hypothesized that the disease-associated human isoforms could play a regulatory role by attenuating the function of the full-length isoform.

Such molecules, including truncated forms of neurexin I and neuroligin (i.e. mimicking autism variants, missing EF metal binding motifs), could serve regulatory roles by attenuating the function of full-length isoforms or behave as soluble signalling molecules [63], [70].

Efforts focused at differentiating or attenuating the function of MDSCs have been promising, leading to improved immune response against the tumor and a better prognosis for the patient [2].

The CD4+CD25− T-cell-derivedGITR+ cells (GITR+ non-Treg) are also known to activate self-reactive T cells by attenuating the function of Tregs, indicating that they may harm the living cells by eliciting autoimmunity.

For instance, artificial TMs imported into transgenic plants were capable of attenuating the functions of corresponding miRNAs [65,68,70].

Classical PTPs dephosphorylate tyrosine phosphorylation to attenuate the function of many receptor tyrosine kinases (Andersen et al., 2001; Andersen et al., 2004).

Decreases of intracellular ATP levels attenuate the function of the HSP90 molecular chaperone; DHA treatment determines a reduction of ATP and so the disruption of the HSP90 function.

Another study revealed that the inhibition of MMP-2 could phenocopy the anti-angiogenesis and anti-invasion effects of miR-29b, whereas, the introduction of MMP-2 could attenuate the function of miR-29b in HCC cells [[ 74]].

Recently, an anchoring protein called Parc, or p53-associated parkin-like cytoplasmic protein [ 36], was found to bind p53 at the nuclear localization domains of p53 and attenuates the function of p53.

For example, 14-3-3β 14-3-3β 14-3-3βnd TSC2 to form a ternary complex and ultimately attenuates the function of the TSC bindsanging ito conformaTSC1 (ShumwandeTSC2, 2003).

Information is required on expression and activity of the growth factors such as IGF-I and myostatin, as well as on the expression levels of their receptors (IGF-IR and activin receptors), smad proteins and the inhibitory binding proteins (e.g., IGFBP-4, follistatin, myostatin propetide), which may enhance or attenuate the function of these growth factors.