Sentence examples for attenuating the downstream from inspiring English sources

Rack1 suppresses the tyrosine phosphorylation of E-cadherin and its binding catenins, attenuating the downstream ubiquitination of E-cadherin, by disrupting Src E-cadherin–Hakai interactionSrc E-cadherinosis of E-cadHakai.

In Arabidopsis, FLS2 is negatively regulated by the kinase-associated protein phosphatase, KAPP, which blocks activated FLS2 signaling and attenuates the downstream innate immune response [15].

Mutating conserved prolines in the Box1 motif or adding JAK inhibitors attenuates the downstream signaling of WSX1, such as phosphorylation of STAT1/STAT3/STAT5 [17].

This suggests that TZD attenuates the downstream signaling pathways induced by endotrophin.

This attenuates the downstream consequences of endotrophin signaling, including a suppression of EMT, fibrosis and angiogenesis, thereby leading to an increase of chemo-sensitivity (Fig 7E).

Treatment with resveratrol suppressed IGF-1R protein levels and concurrently attenuated the downstream Akt/Wnt signaling pathways that play a critical role in cell proliferation.

Moreover, blocking the PI3-K/Akt pathway by intracellular gene transfer of phosphatate and tensin homolog deleted on chromosome 10 (PTEN), which dephosphorylates phosphatidylinositol - 3,4,5 - tris - phosphate (Ptdlns 3,4,5 P3) and attenuates the downstream signals of PI3-K, CIA in rats [ 52].

46 Furthermore, the use of chemical agents that attenuate the downstream effects of hypoxia during culture may also be a feasible strategy to improve islet viability postisolation and prior to transplantation.

In our in vitro studies in NRVMs, selective knockdown of either FHL1 or FHL2 inhibited PKD activation by pro-hypertrophic neurohormonal stimuli and attenuated the downstream phosphorylation of HDAC5, albeit with some differences in their impact on the responses to ET1 against PE (discussed later).

A possible explanation, suggested by differences in competitive receptor binding ability among the TGF-β isoforms (Lyons et al., 1991), is that TGF-β3 acts as a TGF-β1 antagonist in the LP, successfully competing for the same receptor complex on resident VFFs and attenuating the transcription of downstream profibrotic molecules.

The terminator may have played a key role in attenuating the transcription of the downstream genes in this operon.