Sentence examples for attenuating the binding from inspiring English sources

We conclude that phosphorylating the ITAM tyrosines weakens the binding between Ubiquitin and STAM2, and infer that these residues may be critical for the processivity of the internalizing pathway, attenuating the binding affinity of Ubiquitin for STAM2 in response to post-translational modification.

DNA methylation is classically implicated in gene regulation at promoters, where it is proposed to repress transcription initiation by attenuating the binding of transcription factors, and recruiting repressor complexes through the attraction of methyl-CpG binding proteins 7. CGIs rarely become methylated during normal development and most are likely to function as gene promoters 5.

(F) The down-regulation of 5-HT2AR does not attenuate the binding of HCV to host cells.

-Epigallocatechin gallate, at 0.005 μg mL−1 or more, concentration-dependently attenuated the binding affinity on a designed biochip as evidenced by QDs RNA oligonucleotide.

Flutamide administration appeared the tendency to attenuate the binding activity of NF-κB.

This post-translational modification attenuates the binding of hGR to GREs and its ability to influence glucocorticoid-responsive gene expression.

However, they showed that the G allele attenuated the binding of Oct-1 to the promoter region of APE1 and resulted in decreased transcriptional activity.

Cis expression of Sema5A constructs that harbor the sema domain significantly attenuates the binding of bath applied Sema5A-Fc to PlexA2.

Likewise, miR-381 transfection significantly attenuated the binding activity between C/EBPα and Cx43 promoter DNA, whereas this effect was fully rescued by overexpression of an exogenous C/EBPα without the 3′-UTR in MDA-MB-231 cells.

In untreated HepG2 cells an hTERT signal was observed in the Mad and Max immunoprecipitations, whereas in leptin treated cells (200 ng/ml for 48 h ) a strong hTERT signal was ditected in the Myc/Max immunoprecipitations. Interestingly, long term (two months with 100 ng/ml) leptin treatment of HepG2 attenuated the binding of Myc/Max to hTERT promoter.

Moreover, there seem to be fewer constraints with respect to which sites can be targeted in human cells, with at least a few potential sites available within each 100 bp of genomic DNA, although methylation of the DNA target site can attenuate the binding affinity (Bultmann et al., 2012).