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We identify the auxin-dependent transcription factor ARF5/MONOPTEROS to cell-autonomously restrict the number of stem cells by directly attenuating the activity of the stem cell-promoting WOX4 gene.
We validated this finding in vivo using single cells, and attenuating the activity of the mitochondrial inner membrane anion channel with 4-chlorodiazepam to show that the oscillation of NAD(P H and reactive oxygen species (ROS) can be abated in these two evolutionarily distant species.
It is well known that attenuating the activity of inflammatory cytokines in patients with RA inhibits bone resorption and destruction.
These findings suggest that oxytocin can reduce symptoms of anxiety which is likely, due in part, to attenuating the activity of the HPA axis [ 8].
In health, its principal role is to protect against excessive bone turnover during times of increased need by attenuating the activity of osteoclasts [ 25].
A circulating protein called plasminogen activator inhibitor 1 (PAI-1) inhibits serine proteases such as t-PA, thereby attenuating the activity of the fibrinolytic system in blood.
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Because DUSP4/6 and SPRY4 are negative regulators for ERK1/2 and RTK, respectively [31, 61, 110], these observations may suggest that ETS1 is required for robust RAS/ERK pathway activation, and reducing its activity would attenuate the activity of ERK1 and ERK2.
Repetitive transcranial magnetic stimulation is increasingly used as a therapeutic tool in psychiatry and has been demonstrated to attenuate the activity of the stress hormone system.
In the primary feedback loop, PER and CRY assemble into repressor complexes next attenuate the activity of CLOCK BMAL1.
Nevertheless, in oxidative stress conditions, ERK1/2 might adopt a pro-apoptotic role since they attenuate the activity of protein kinase B (PKB, EC 2.7.11.1), called also AKT1 [159].
However, the results of Go's study is exactly contrary to ours which indicated that pre-treatment with VPA significantly attenuated the activity of NF-кB pathways and led to the protective effect on nervous system.
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