Sentence examples for attenuating the activation from inspiring English sources

In concordance to that, our study demonstrated that PTE pre-treatment prior to H2O2 injury to cells protected the dIMR32 cells by attenuating the activation of ERK1/2.

We demonstrated for the first time that PGE2 can suppress the production by attenuating the activation of Akt and JNK through the EP2 and 4/cAMP/PKA pathway in SD-Mg.

Epigenetic regulation has a functional role in attenuating the activation of the CEBPD promoter in response to external stimuli.

Thus, the less harmful effects of HFO may be mediated by attenuating the activation of epithelial and endothelial cells.

Our previous study demonstrated that FC-98, a benzenediamine derivate, inhibited the TNF- α, IL-6, MCP-1, and NO production from LPS-induced murine macrophages through attenuating the activation of NF- κB, JNK, and IRF3 signaling pathway.

Our laboratory had recently demonstrated the small molecule compound FC-98 which can inhibit the expression of TNF- α, IL-6, MCP-1, and NO from LPS-induced mouse macrophages through attenuating the activation of NF- κB, JNK, and IRF3 signaling pathway.

Our results demonstrate for the first time that leptin attenuates the activation and transcriptional activity of NF-κB by reducing the acetylation of the p65 subunit in a SIRT1-dependent manner.

In 500 μM H2O2-stimulated rat aortic smooth muscle cells, raxofelast dramatically attenuated the activation of mitogen-activating protein kinase (MAPK /ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression.

Therefore, though therapeutic dose might attenuate the activation of primary stellate cells to their activated form, the treatment with 100 nM EVE (which is higher than the recommended through level in the liver transplant) significantly induced an increase in α-SMA, VIM and FN expression.

Therapeutic hypothermia, however, did not attenuate the activation of the p38 and JNK pathways, but activated the ERK pathway, which seemed to be dose dependent with the duration of therapeutic hypothermia.

Further analysis demonstrated that SMC1A silencing attenuates the activation of Erk1/2 and Akt, which are generally activated in response to growth factor stimulation that transmits growth and survival signals [ 30].