Sentence examples for attenuating platelet aggregation from inspiring English sources

It has been shown also that a period of brief myocardial ischemia and increased cardiac adenosine production are capable of attenuating platelet aggregation in remote arteries [ 53].

Secondly, treatment with the ROK inhibitor Y27632 attenuated platelet aggregation independent of significant changes in the phosphorylation state of [Thr855]MYPT and phosphorylation of MLC20.

There are several alternative mechanisms by which ROK inhibition might attenuate platelet aggregation independent of changes in MLC20 phosphorylation [53], and these are illustrated in Figure 1.

In the whole blood assay, Pred (tested at 10 μM) failed to significantly attenuate platelet aggregation elicited by arachidonate or collagen (Table 1).

Thus we have demonstrated that PF-228 abolishes platelet aggregation, significantly attenuates platelet spreading and appears to selectively inhibit the activity of kinases that have been shown to be involved in FAK-dependent processes.

We postulated that diminished MLC20 phosphorylation, resulting from reduced ROK-dependent inhibition of MLCP, attenuated platelet contraction and hence aggregation in sepsis.

C. CR50 attenuates HNP-stimulated platelet aggregation in ADP-primed human platelet rich plasma.

As shown in Figure 3D, K-11 scFv, but not KM10 scFv, was able to attenuate Aggrus-induced platelet aggregation.

Because K-11 scFv, but not KM10 scFv, attenuated Aggrus-induced platelet aggregation in vitro, we then examined the inhibitory effect of K-11 scFv on pulmonary metastasis in vivo.

Pharmacologic intervention with clopidogrel and aspirin during acute coronary syndromes and percutaneous coronary intervention is considered the gold standard for attenuating platelet activation and aggregation.

Chang et al. further demonstrated that the effect of phloroglucinol in attenuating arachidonic acid-induced platelet aggregation was closely related to a decrease in ROS production.