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Gabapentin has been reported to be effective for pain associated with various peripheral neuropathies in clinical trials [ 50, 51], but requires several weeks of treatment before an attenuating effect is observed.
This attenuating effect is the result of volume-mediated inhibition of proximal tubular salt and water reabsorption and decreasing contact time from the associated increase in tubular flow [ 24].
However, adjustment for BMI (which had the most potent attenuating effect) is unlikely to represent an overadjustment, since weight gain is associated with an increase in CRP, and weight loss with a CRP reduction [49] [51].
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The attenuating effect was seen over a wide range of doses, from 3 µg/kg to 3 mg/kg (Figure 6C).
A similar attenuating effect was observed for the pro- and anti-apoptotic transcription factors Dp5, Atf3, and Mcl-1 (Fig. S5).
"We find that the tax system helped mitigate somewhat the increase in household income inequality over the sample period, but this attenuating effect was insufficient to significantly alter the broad trend toward rising inequality," the researchers conclude.
With the use of esmolol, significant attenuating effects were found on cardiovascular parameters in the first 5 min after stimulation; its shortening effects on seizure duration may be dose-related.
Weaker but significant attenuating effects were observed in sub-cortical nuclei of the thalamus, hypothalamus, and striatum and hippocampus (Figure 5).
Upheaval and pain make you insular, and a good way to attenuate their effect is to look outwards: to find the energy and the curiosity to engage with the wider world again.
Characterisation of the genetic basis of this attenuated QTL effect is important to our understanding of the genetic mechanisms of complex traits.
Comparable and slightly attenuated effect estimates were observed for all physical activities with a 1-year mean level of NO2 at the cohort baseline (data not shown).
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