Ahrenhoerster, L. S., Tate, E. R., Lakatos, P. A., Wang, X. & Laiosa, M. D. Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates capacity of hematopoietic stem cells to undergo lymphocyte differentiation.
Furthermore, RBP-J-deficient macrophages displayed attenuated capacity to activate T cells (Wang et al., 2010).
Those that caused the highest increase in ROS levels in EMEM/S- had a significantly attenuated capacity to induce ROS in the Hep G2 cells in EMEM/S+ medium.
Furthermore, we have previously shown that RBP-J deficient SEC have attenuated capacity in supporting hepatocyte regeneration due to the lowered level of VEGFR1 expression [26].
However, we consider this possibility unlikely as further stimulation of B2 cells in GF PP-DC cultures by IgM cross-linking antibodies did not increase IgA levels, demonstrating that optimal BCR stimulation does not alter the attenuated capacity of GF PP-DC to promote IgA production (data not shown).
Its presence there interferes with IgG binding to FcγRIIIa leading to an attenuated capacity to destroy invading cells through antigen-dependent cell cytotoxicity (ADCC) activity.
The aged environment had the reverse effect, in that NK cells from a young origin developing in an aged environment had an attenuated capacity to degranulate and produce IFN-γ similar to their aged counterparts, but substantially less than those developing in a young environment (Fig. 5).
In a mouse partial hepatectomy (PHx) model, RBP-J deficient EPC showed attenuated capacities of homing and facilitating liver regeneration.
Thus it has been suggested that high expression of PPAR γ and low expression of COX-2 in the tumours might be involved in attenuating the capacity of the tumours to develop more malignant nature.
This TAM-like population was also characterized by an attenuated phagocytic capacity when incubated with microbial particles (Fig. 1e, Supplementary Fig. 1f).
