Sentence examples for attenuates the interaction of from inspiring English sources

Further co-IP experiments proved that overexpression of KSR1 attenuates the interaction of SIRT1 DBC1, which therefore allows SIRT1 to interact more with p53 resulting in decreased p53 acetylation.

Specifically, SMYD2-mediated monomethylation of p53 K370 attenuates the interaction of p53 with p53 target promoters and consequently antagonizes p53-dependent transcriptional regulation [ 112].

De-conjugation of SUMO2/3 by SENP3 attenuated the interaction of Sp1 with RNF4.

Deletion of the CL4-binding region (C-CPE303) attenuated the interaction of C-CPE with CL4-BV (Fig. 1C).

It was thought to exert its effect through decreasing the viability of T helper type 1 cells and attenuating the interaction of T cells with macrophages.

Reciprocally, changes to gene expression by sAPPα via the activation of NF-κβ may attenuate the interactions of Aβ [ 77] and this can be understood as reciprocal indirect feedback from the α-pathway on the β-pathway.

Importantly, lnc-CRCMSL controls the cytoplasmic retention of HMGB2 and attenuates the interaction between HMGB2 and OCT4 to suppress EMT.

In the present study, we demonstrated that phosphorylation of FE65 Ser by SGK1 attenuates the interaction between FE65 and APP.

Phosphorylation of p53 at Ser promotes p53 stabilization by attenuating the interaction between p53 and its negative regulator MDM2.

MLL-ENL has been shown to attenuate p53 function, since it antagonizes the interaction of p53 with the p300/CBP co-activator [56]; it is conceivable that this activity of MLL-ENL counteracts the induction of differentiation by low levels of active p53, such as might be present in cells expressing oncogenic RAS in the absence of cytarabine.

This interaction downregulates the transcriptional activities of cytokine genes and attenuates the synthesis of the corresponding proteins.