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In addition, Bcl-2 heterozygous knock-out mice show some behaviors similar to mania, including increased reward seeking and amphetamine sensitization, and lithium pretreatment attenuated sensitization in these animals (Lien et al. 2008).
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XIAP-knockdown attenuated sensitivity of SH122 to TRAIL-induced cytotoxicity, confirming that XIAP is an important target for IAP-inhibitor-mediated TRAIL sensitization.
However, both male and female TS rats exhibited attenuated AMPH sensitization compared to sex-matched controls.
Baclofen (1.25, 2.5 and 5 mg/kg), administered for 5 days prior to cocaine, dose-dependently attenuated cocaine sensitization.
GR 55562 (0.1 10 μg/side), administered for 5 days into the accumbens shell, but not into the core, prior to cocaine dose-dependently attenuated cocaine sensitization.
In wild-type mice, wortmannin or peptide competition attenuated the sensitization.
MiR-138 over expression enhanced cellular sensitivity to cisplatin and reintroduction of histone γH2AX in miR-138 overexpressing cells attenuated the sensitization to cisplatin [ 31]. miR-138 is inversely correlated with excision repair cross-complementing rodent repair deficiency, complementation group 1 (expressionressinn in the A549/DDP multidrug-resistant human lung adenocarcinoma cells.
The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine.
Inhibition of substance P and glutamate release can attenuate central sensitization and, consequently, could decrease pain.
NMDA antagonists may inhibit or attenuate central sensitization [ 97] and potentially reduce pain associated with fibromyalgia.
Insulin resistance is associated with upregulation of the same inflammatory pathways that can be attenuated by insulin sensitization treatment.
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