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Variants in THADA have been associated with diminished insulin secretion during GLP-1 treatment (65), whereas variants in the MTNR1B gene were associated with reduced insulin responses to GLP-1 stimulation, but the attenuated responsiveness was also observed for other β-cell stimuli and also during intravenous glucose, indicating a global β-cell defect (53, 55).
Previously we could demonstrate attenuated responsiveness of the hypothalamus pituitary adrenal (HPA) axis to stress in patients with chronic allergic inflammatory disease (i.e., atopic dermatitis, allergic asthma).
However, attenuated responsiveness to dsRNA does not necessarily limit HCVcc infection in specific cell lines because the Huh7-3 celineine, which supported equally robust HCVcc infection, showed high IFN stimulated gene induction in response to dsRNA.
In the present paper, we report that VEGF-A suppressed the amount and/or activity of ILMR, a secreted agent that attenuated responsiveness of cells to LPA.
A ceiling effect results in a positively skewed distribution of measurements, limited ability of the measure to discriminate among subjects at the upper end of the scale, and attenuated responsiveness to improvements in health in longitudinal studies.
Evolution in captivity is associated with a set of phenotypic changes, including enhanced growth rate [ 4- 6], attenuated responsiveness to stress [ 7, 8], increased feeding behavior [ 9], and reduced predator avoidance behavior [ 6, 10, 11].
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In this report, we considered one explanation for this paradox: that ECs secrete agents that attenuate responsiveness to LPA.
The A −816 C variation attenuates responsiveness to clopidogrel in patients diagnosed with coronary heart disease.
Concomitant treatment with oral corticosteroids did not appear to attenuate responsiveness to PPV23 or TTV (data not shown); however, this should be confirmed in larger studies.
The present study clearly showed that bronchial responsiveness did not change after relief of cough without use of ICS, and long-tem ICS attenuated bronchial responsiveness to inhaled methacholine in patients with cough variant asthma, probably resulting in prevention of development of typical asthma from cough variant asthma.
Surprisingly, A0023 also showed attenuated brain responsiveness compared to wild type (Figure 3B).
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