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Addition of nutlin restored doxorubicin-induced p53 protein and transcriptional activity in senescent cells to the levels in early passage cells but only partially restored its apoptotic activity, suggesting that changes in both upstream and downstream p53 signaling during senescence are responsible for attenuated response to genotoxic stress.
Nine of these patients (13.8%) were unresponsive and nine patients (13.8%) had attenuated response to second lithium treatment.
In addition to an attenuated response to lifestyle programs, AA women also demonstrate high rates of obesity, diabetes, and cardiovascular disease.
Furthermore, this polymorphism tends to show an attenuated response to an HMG-CoA reductase inhibitor in terms of the cholesterol lowering effect.
Furthermore, removal of NeuAc residues from nerve cells reverses MAG-mediated inhibition of neuritogenesis, and neurons from mice lacking the 'NeuAcα3Gal β3GalNAc' terminus have an attenuated response to MAG.
In our sample, older fathers found infant cries less aversive and had an attenuated response to infant crying in both the dorsal anterior cingulate cortex (dACC) and the anterior insula, suggesting that compared with younger fathers, older fathers may be better able to avoid the distress associated with empathic over-arousal in response to infant cries.
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Global deletion of PrRP (in a loxSTOP lox- PrRP mouse) results in obesity and attenuated responses to leptin and CCK.
TRPV1-deficient mice show attenuated responses to heat stimuli [ 5] but other molecules seem to contribute to noxious heat sensations as well [ 23].
SK-N-AS cells also had consistently attenuated responses to activator BH3 peptides and may have resistance mechanisms in place downstream of Bcl-2 signaling.
TRAF1-deficient dendritic cells, however, show attenuated responses to secondary stimulation by TRAF2-dependent factors, suggesting a positive regulatory role in these cells.
Habituation, i.e. the way the nervous system attenuates response to repeated non noxious stimuli is a fundamental function of sensory systems, that allows appropriate adaptation of neural responses to the relevance of incoming stimuli.
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CEO of Professional Science Editing for Scientists @ prosciediting.com