Hearts perfused by allogeneic pig blood sustained normal function throughout the study period, while those perfused with human blood lost organized ventricular contraction in 25-34 min with markedly attenuated function.
Mitochondria isolated from β-cells derived from β-cell specific insulin receptor knockout (βIRKO) mice exhibited reduced BADS, GK and protein kinase A in the complex, and attenuated function.
For many, although not all of the predicted dysregulated pathways, there is an extensive literature that provides evidence for attenuated function in HD mouse models and HD patients (reviewed for example in [ 43, 44]).
Given this observation, it is reasonable to consider that quasi-specific sites can substantially attenuate functions of transcription factors in vivo and that quasi-specific sites might play a role in the regulation of transcription factors via indirect interplay with other nuclear proteins.
These results demonstrate that LCs exert an attenuating function on psoriatic skin inflammation, whereas Lan+ DDCs and other Langerin-expressing DC subsets were dispensable for the progression of the psoriatic phenotype.
With age, an overall functional decline in the hematopoietic system is characterized by reduced lymphoid cell and increased myeloid cell population with attenuated immune functions.
One recent study demonstrated that anti-CD39 specific blocking mAb attenuated immunosuppressive functions of Treg and restored CD4+ and CD8+ T cells (Nikolova et al, 2011), suggesting a potential role for CD39 in regulating T-cell-mediated antitumour immunity.
In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic cardiomyopathy.
It was found that bilateral injection of ketanserin (250 pmol for each side) into the NTS not only significantly increased blood pressure, but also attenuated baroreflex function.
So, when searching for your organization's next leader, look for someone with an attenuated dopamine function: someone who is never satisfied with the status quo, someone who wants the feeling of success more than others — but likes it less.
Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function.
