Whereas treatment of control HEEs with arachidonic acid increased expression of inflammatory cytokines, 12-hydroxy-eicosatetraenoic acid attenuated expression of late differentiation markers.
In addition, RBP-J-deficient DCs exhibited attenuated expression of the antigen presenting molecules MHC II, co-stimulatory molecules CD80 and CD86 in response to tumor antigens and displayed a reduced capacity to activate T cells in relation to T cell proliferation, T cell cytokine production (IFNγ and IL-4) and cytotoxicity (Feng et al., 2010).
Rats in which ibotenic acid had been injected into the BNST showed attenuated expression of c-Fos in the hypothalamic paraventricular nucleus (PVN) and blunted elevation of plasma adrenocorticotropic hormone (ACTH) after microinjection of neostigmine into the hippocampus compared with rats in which saline had been injected into the BNST.
We later confirmed attenuated expression of Vegf mRNA in response to motor nerve stimulation in skeletal muscle (Fig. 3A).
A variety of vasculopathies shift the phenotype of SMC from one of quiescence and contractile competence to proliferation, migration, matrix production, and attenuated expression of contractile proteins [1].
Within 43 to 77 days of cultivation (7 to 12 passages), MSC demonstrated morphological abnormalities, enlargement, attenuated expression of specific surface markers, and ultimately proliferation arrest.
Lung fibroblasts derived from Egr-1−/− mice also showed remarkably attenuated expression of LC3B and Atg4B (Fig. 5C) in response to CSE or TSA.
We systematically attenuated expression of genes within the minimally defined 19q12 region in ovarian cell lines using short-interfering RNAs (siRNA) to identify driver oncogene(s) within the amplicon.
As shown in Figure 3, silencing of the NR2F2 gene in villous cytotrophoblast cells undergoing differentiation significantly attenuated expression of the TFAP2A gene and the genes for hPL, pregnancy specific glycoprotein 1 (PSG1) and corticotropin releasing hormone (CRH), all of which are markedly induced during the differentiation process.
These observations suggest that attenuated expression of this protein contributes to genomic instability and carcinogenesis.
We propose a novel causal relationship between relaxin expression, attenuated expression of S100A4 and reduced tumour growth.
