Furthermore, we observed that AGEs-induced cell migration was attenuated by using LY294002, a PI3K/AKT inhibitor, in macrophages.
While excitotoxicity is typically attenuated by using glutamate receptor antagonists, we report here that neuronal deaths induced directly by brief exposures to glutamate or NMDA were both attenuated by preincubation with platelet-derived growth factor-BB (PDGF-BB).
In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [37].
In multivariable analysis (Additional file 4: Table S4a) the odds ratio for the association between South Asian ethnicity and stillbirth was very slightly attenuated by using lower BMI thresholds to define overweight and obesity (aOR for South Asian women using alternative BMI thresholds 2.26, 95% 1.37-3.72; aOR using conventional thresholds 2.33, 95% 1.42-3.83).
In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [ 37].
Low-frequency acoustic radiation is extremely difficult to attenuate by using passive devices.
Absorption bands near 155 nm due to electronic transitions of CH3OH, CH3OD, CD3OH and CD3OD in a liquid phase were observed by using a uniquely designed attenuated total reflectance far ultraviolet (ATR FUV) spectrometer.
Near-ambient solar UV-B (approximately 84 88% of solar UV-B) was provided by using a Teflon film, attenuated solar UV-B radiation (43 49% reduction in solar UV-B) by using a cellulose acetate film, and supplemental UV-B radiation by the use of UV fluorescent lamps (two levels: 5.30 and 8.50 kJ m−2 day−1).
We show that the expression levels of HIF-1alpha can be significantly attenuated by use of the recently established small interfering RNA technology in combination with adenovirus-mediated gene transfer.
It did not require novel protein synthesis nor did it show extensive nuclear fragmentation, but it was attenuated by use of caspase inhibitors.
