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Aprotinin is a broad-spectrum serine protease inhibitor that has been shown to attenuate the systemic inflammatory response in patients undergoing cardiac surgery with cardiopulmonary bypass.
Steroids attenuate the systemic inflammatory response syndrome (SIRS) and improve cerebral perfusion.
Specifically, we were unable to attenuate the systemic inflammatory response despite evidence of anti-inflammatory activity in preclinical disease models.
This study showed that, in a rodent model of laparotomy and endotoxemia, dopexamine can attenuate the systemic inflammatory response, limit the degree of lactic acidosis, and protect against organ injury.
In this model, dopexamine can attenuate the systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow.
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For example, treatment with c-peptide after the induction of endotoxic shock in mice attenuated the systemic inflammatory response and improved survival compared with vehicle [6].
Low tidal volume (VT) ventilation in intensive care patients without lung injury attenuates the systemic inflammatory response [ 1].
In humans, oral intake of simvastatin for 4 days attenuates the systemic inflammatory response to intravenous LPS [ 12].
Our results show that long-term antithrombin III supplementation attenuates the systemic inflammatory response in patients with severe sepsis.
We hypothesized that volatile anesthetics might reduce morbidity and mortality by attenuating the systemic inflammatory syndrome provoked by cecal ligation and puncture (CLP).
Murine models of pneumococcal pneumonia [ 18], multiple trauma [ 19] and abdominal sepsis [ 20, 21] reveal that depletion of NK cells prolongs survival and attenuates the systemic inflammatory reaction whereas the presence of NK cells is consistent with amplification of the inflammatory reaction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com