The analytical approach also shows that control by overall feedback inhibition amplifies the regulation of flux by the demand for end product while attenuating the sensitivity of the concentrations to the same demand.
Partial restoration of MDM2 attenuated the sensitivity enhancement by miR-181b.
As for the insulin tolerance tests, CR attenuated the sensitivity of GHR-KO females to 0.75 U.S.P.U./kg B.W. of insulin [(p = 0.0483),].
This may be one way of attenuating the sensitivity of the normal mammary epithelium to the effects of the ovarian steroids and of ensuring that significant proliferative activity occurs only when it is needed (i.e. during puberty and pregnancy).
This fact suggests that ubiquitination-dependent downregulation of IFNAR1 represents a major and critically important mechanism that attenuates the sensitivity of cells and tissues to IFN and plays a key role in limiting IFN-mediated immunopathology.
The percentage of red/green fluorescence ratio in pSM30-miR-212 compared with pSM30-SCR-transfected cells was significantly lower in cells carrying the wild-type (pmChKir2.1UTR) compared with the mutated (pmChKir2.1UTRm212) construct, demonstrating that the mutation attenuated the sensitivity to miR-212.
Furthermore, injection of wild type mice with LPA led to a noticeable downregulation of IFNAR1 protein (but not mRNA) on splenocytes (Fig 7B) and attenuated the sensitivity of these cells to IFN in vitro as assessed by IFN-induced activation of STAT1 (Fig 7C).
The results of the present study show that low doses of O3 exposure for long periods attenuate the O3 sensitivity of tobacco Bel-W3 seedlings.
The cough sensitivity to hypertonic aerosols is associated with asthma [ 11- 15] and treatment with ICS attenuates the cough sensitivity to them [ 11].
Moreover, modulated expression of Prxs with small interfering RNA (siRNA) or transfection can potentiate or attenuate, respectively, the sensitivity of radiotherapy and chemotherapy linked with clinical outcomes and overall patient survival.
