The phrase "attenuate the pathogenesis" is correct and usable in written English.
It can be used in a scientific or medical context when discussing the reduction or weakening of the development of a disease or condition.
Example: "The new treatment aims to attenuate the pathogenesis of the disease, thereby improving patient outcomes."
Alternatives: "reduce the pathogenesis" or "diminish the pathogenesis".
Previous studies have shown that Cxcl12 is a catabolic factor that can infiltrate cartilage, reduce proteoglycan content, and increase MMP-13 activity.45 Inhibiting the Cxcl12/CXCR4 signaling pathway can attenuate the pathogenesis of OA.46 Moreover, it also induces the migration of bone marrow MSCs to articular lesion sites.
Wild-type HSV-2 MS (ICP0+) virus was included as a control to verify that the 0ΔNLS mutation was necessary to attenuate the pathogenesis of HSV-2 infection.
In addition, PPAR agonists have been reported to exert beneficial effects by attenuating the pathogenesis of heart failure and atherosclerosis [ 14, 15].
By extension, blockade of TRPV4 activity may be expected to attenuate the circulatory dysfunction that underlies sepsis pathogenesis.
The enlargement of the tibial plateau bone may attenuate the tibial cartilage, and this attenuation may play a role in the pathogenesis of OA [ 15].
These data demonstrate that enhancement of autophagic degradation could attenuate the SiNPs-induced PF, and further testify inhibition of autophagic degradation is involved in the pathogenesis of SiNPs-induced PF.
Although the mechanistic role of vitamin D deficiency in the pathogenesis of dyslipidemia is not well understood, vitamin D supplementation was reported to attenuate the beneficial effect of hormone replacement therapy on serum lipid levels (21).
Autocrine TGFβ signaling has been reported to play a major role in the pathogenesis of SSc. and blockade of endogenous TGFβ signaling has been shown to attenuate the scleroderma fibrotic phenotype [ 8].
Conclusions: These data, along with our previous finding showing rotenone-induced toxicity was prevented by the autophagy enhancers and was aggravated by the autophagy inhibitors in SH-SY5Y, suggest that autophagy contributes to the pathogenesis of PD, attenuates the rotenone toxicity and possibly represents a new subcellular target for treating PD.
These data, along with our previous finding showing rotenone-induced toxicity was prevented by the autophagy enhancers and was aggravated by the autophagy inhibitors in SH-SY5Y, suggest that autophagy contributes to the pathogenesis of PD, attenuates the rotenone toxicity and possibly represents a new subcellular target for treating PD.
To test whether disruption of SDF-1 signaling could attenuate OA pathogenesis in vivo, we treated the primary Hartley guinea pig OA model with AMD3100, a specific nonpeptide CXCR4 chemokine receptor antagonist [ 35].
