The phrase "attenuate the host" is correct and usable in written English.
It can be used in contexts related to biology, medicine, or technology, particularly when discussing the reduction of the effects or strength of a host organism or system.
Example: "The researchers aimed to attenuate the host's immune response to improve the efficacy of the vaccine."
Alternatives: "weaken the host" or "reduce the host's response".
RNF216 may function to attenuate the host response to viral invasion, as RNF216 ubiquitinates TRAF3, a potentiator of the anti-viral response, and targets it for proteasomal degradation [ 20].
39, 40 Second is development of immunoregulatory responses by the host that attenuate the host response to parasite products such as anti-inflammatory cytokines such as interleukin-10, expansion of malaria-specific regulatory T cells, 41– 43 and/or B- and T-cell exhaustion.
Plasma exchange, however, also has the potential to cause harm by diluting or attenuating the host's adaptive response to infection.
Indeed, previous work has proposed that mycobacterial antigens, such as the early secreted antigenic target protein 6 (ESAT-6) protein, attenuates the host innate immune response by inhibiting MYD88-IRAK4 binding, thus causing suppression of NF-κB-induced transcription of upstream genes required for T cell response initiation [ 66].
For example, history of TB in the family context, history of previous contact with TB and previous TB diagnosis and/or treatment, and any condition attenuating the host immune system [ 4] are common risk factors for TB that should be considered as relevant to guide the correct diagnosis.
The defensin deficiency is proposed to attenuate the antibacterial host defense capacity of the intestinal mucosa, and may initiate and/or perpetuate the chronic inflammation characterizing the disease at this site [7] [12].
Many lines of evidence have revealed that HCV-mediated phosphorylation and activation of PKR, in turn, inhibit its downstream target, eIF2α, and attenuate the expression of host cellular proteins, including ISGs, without any inhibitory effects on viral IRES-mediated viral protein translation (Table 1).
Obviously, the robust synthetic gene network by the proposed sub-minimax regulation design method has robust stability to the uncertain initial conditions and enough filtering ability to attenuate the disturbances on the host cell and can approach the desired steady states.
(F) The down-regulation of 5-HT2AR does not attenuate the binding of HCV to host cells.
Immune systems have evolved, at great cost, partly to attenuate the impacts of pathogens on host fitness.
In phagocytes, many of these genes are dedicated to an effective immune response for clearing the pathogen yet Mtb is able to attenuate this host defense.
