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These adverse events can limit the ability to deliver adjuvant treatment because of needed dose reductions and scheduling delays, which may attenuate the effectiveness of regimens designed to improve survival or cure patients with early-stage breast cancer.
However, many operational, social and technical barriers may attenuate the effectiveness of such interventions.
The EGFR-FOXO6-SOX2 signaling pathway regulating expression of the BIM and BMF apoptotic factors thus identifies a feedback loop that may attenuate the effectiveness of anti-EGFR therapy in cancer and contribute toward the ultimate development of drug resistance.
Under real-world conditions in resource-limited settings a variety of factors attenuate the effectiveness of PMTCT interventions, including resource limitations, inadequate laboratory capacity, health system inefficiencies, and client loss-to-follow-up [ 9, 10].
Although in the present review, we could not adequately determine the effects of tobacco smoke exposure on the relationship between inhaled corticosteroids and airway inflammation, there is a growing body of evidence to suggest that active smoking may attenuate the effectiveness of corticosteroids in suppressing airway inflammation.
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Repeated administration of buspirone attenuates the effectiveness of somatodendritic 5-HT1A receptors.
Cyclical mechanical stretch attenuated the effectiveness of TGFβ in inducing myofibroblast differentiation.
Replacement of the positive charge in the K624A or K624E construct or increasing the positive charge in the G625K and 3xK construct either completely blocks or attenuates the effectiveness of the these GSMs.
The studies found isomiRs with 3′ end additions may increase miRNA stability in Drosophila [ 41] and be involved in the pathogenesis of many human diseases [ 42], and also attenuated the effectiveness of some specific miRNAs [ 43, 44].
We demonstrate that cell deformation via cyclical biaxial strain attenuates the effectiveness of TGFβ in inducing myofibroblast differentiation while simultaneously inducing BNP and NPRA production in human cardiac fibroblast cells.
These results are hypothesis generating to reduce health and sociodemographic disparities nationally, policies that attenuate the effects of socioeconomic stressors must be judiciously tested to evaluate if they enhance the effectiveness of health promotion strategies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com