The phrase "attenuate the downstream" is correct and usable in written English.
It can be used in contexts related to reducing or diminishing effects or impacts in a downstream process, often in scientific or technical discussions.
Example: "The new filtration system is designed to attenuate the downstream effects of pollutants in the water supply."
Alternatives: "reduce the downstream" or "diminish the downstream".
In Arabidopsis, FLS2 is negatively regulated by the kinase-associated protein phosphatase, KAPP, which blocks activated FLS2 signaling and attenuates the downstream innate immune response [15].
Mutating conserved prolines in the Box1 motif or adding JAK inhibitors attenuates the downstream signaling of WSX1, such as phosphorylation of STAT1/STAT3/STAT5 [17].
This suggests that TZD attenuates the downstream signaling pathways induced by endotrophin.
This attenuates the downstream consequences of endotrophin signaling, including a suppression of EMT, fibrosis and angiogenesis, thereby leading to an increase of chemo-sensitivity (Fig 7E).
Treatment with resveratrol suppressed IGF-1R protein levels and concurrently attenuated the downstream Akt/Wnt signaling pathways that play a critical role in cell proliferation.
Moreover, blocking the PI3-K/Akt pathway by intracellular gene transfer of phosphatate and tensin homolog deleted on chromosome 10 (PTEN), which dephosphorylates phosphatidylinositol - 3,4,5 - tris - phosphate (Ptdlns 3,4,5 P3) and attenuates the downstream signals of PI3-K, CIA in rats [ 52].
Rack1 suppresses the tyrosine phosphorylation of E-cadherin and its binding catenins, attenuating the downstream ubiquitination of E-cadherin, by disrupting Src E-cadherin–Hakai interactionSrc E-cadherinosis of E-cadHakai.
In our in vitro studies in NRVMs, selective knockdown of either FHL1 or FHL2 inhibited PKD activation by pro-hypertrophic neurohormonal stimuli and attenuated the downstream phosphorylation of HDAC5, albeit with some differences in their impact on the responses to ET1 against PE (discussed later).
These observations support that dysregulated hypothalamic leptin signaling following chronic SCI attenuates both the downstream production of POMC and anorexigenic neuroendocrine pathways associated with the primary melanocortin system, and in parallel, NPY-ergic inhibition, resulting in exacerbated orexigenic effects.
Further studies revealed that the reintroduction of miR-449a attenuated the downstream signaling of Met, and consequently reduced the accumulation of Snail in cell nucleus by targeting the 3'-untranslated regions (3'-UTR) of FOS and Met.
