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NaHCO3 increased the rate of La− efflux from the muscle group, but did not attenuate the decline in muscle tension as compared to control conditions [56].
NaHCO3 appears to delay the rise in muscle interstitial K+ that occurs during intense contractile activity and, via this effect, may attenuate the decline in muscle membrane excitability and the extent of K+-induced K+-inducedon of myocytes durinactivationivity [11, 66].
"Our study suggests that eating more fruits on a regular basis can help attenuate the decline as people age, and might even help repair damage caused by smoking.
Dexpramipexole, an enantiomer of pramipexole, is thought to have anti-inflammatory properties and was recently found to attenuate the decline in function using the ALS Functional Rating Scale-Revised (ALSFRS) in a dose-dependent manner with good tolerability in ALS [ 55].
A separate study that also involved a variety of exercises (flexibility, strength, endurance, coordination) for 17 weeks failed to increase the delayed-type-hyphersensitivity (DTH) response to 7 antigens, but tended to attenuate the decline in the response over time (although this did not reach statistical significance).
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In contrast, progesterone treatment prolonged pregnancy beyond day 25 and attenuated the decline in RGS2 messenger RNA levels.
Interrupting disuse by 15 minutes of weight-bearing activities attenuated the decline in bone formation and increase in osteoclast number but not the loss of bone tissue.
In addition, we found that add-on aliskiren attenuated the decline in GFR in hypertensive nephropathy patients.
Treatment with the IL-6 receptor antibody attenuated the decline in circulating testosterone (Fig. 5A) and testicular atrophy (Fig. 5B).
Add-on direct renin inhibitor aliskiren (150 mg daily) safely reduced proteinuria and attenuated the decline in GFR in the non-DM CKD patients who were receiving ARBs.
Treatment with MG132 inhibitor completely attenuated the decline of Mcl-1 in CHX-treated human mammary epithelial cells, confirming the involvement of the 26S proteasomal degradation pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com