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Animals were not treated with insulin or oral hypoglycemics because the purpose of the study was to determine the effects of diabetes on diaphragm gene expression rather than the extent to which treatment of diabetes would attenuate the changes.
Taken together, these results suggest that U0126 may attenuate the changes in chondrocyte gene expression towards a catabolic phenotype while allowing for inflammatory processes to be undisturbed.
The analog also showed a tendency to attenuate the changes in other behavioral parameters (Fig. 1 B, C, D and 2).
For instance, Hughey et al. [ 45] have examined the efficacy of mesenchymal stem cell transplantation to attenuate the changes in cardiac function and intermediary metabolism found in myocardial infarction and insulin resistance.
It was hypothesised that curcumin ingestion would attenuate the changes in indirect muscle damage markers and inflammatory markers in the blood after eccentric exercise when compared with placebo condition.
These results did not fully support the hypothesis that curcumin ingestion would attenuate the changes in the muscle damage markers after eccentric exercise, but showed that the curcumin was effective for some aspects of muscle damage.
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In addition, women who refused HIV screening at follow-up were not excluded from the study, which may potentially attenuate the change in body composition measurements.
Ram treatment significantly attenuated the changes in LVEDP (61%) and FS (27%).
Icariin and p-icariin also attenuated the changes in oxidative stress and liver injury.
The administration of DML attenuated the changes in TSH levels and GR and GST activities in MeHg-exposed rats.
Furthermore, conivaptan attenuated the changes in left ventricular end-diastolic pressure, and lung and right ventricular weight.
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