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Monotherapy with AS-IV or FA alone did not attenuate the accumulation of fibronectin, but AF treatment resulted in a significant reduction of fibronectin (P < 0.05, Figure 2).
Furthermore, the heat-induced aggregation of ALDH2 was significantly inhibited by flurbiprofen (Fig 6C), which supported the hypothesis that flurbiprofen can attenuate the accumulation of unfolded proteins, thereby reducing ER stress.
[ 18] Healthy physical activity levels among older women can act to decrease the amount of weight gain experienced during menopause and may attenuate the accumulation of adipose tissue in the upper and central body regions after menopause.
Targeted activation or blocking of the G-protein-coupled receptor (GPCR) signaling pathway and direct inhibition of adenylate cyclase by pharmacological compounds seems to improve photoreceptor cell survival, preserve photoreceptor function and attenuate the accumulation of pathological autofluorescent protein deposits produced by degenerating photoreceptors in the retina (Chen et al., 2013).
In recent studies, FTY720 has been shown to inhibit the development of obesity in high fat fed mice, by modulation of adipogenesis and lipolysis [ 105], and to attenuate the accumulation of ceramide in muscles, associated with a high fat diet, resulting in improved whole body glucose homeostasis [ 106] and amelioration of prediabetic type 2 disposition.
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In addition, DMTU attenuated the accumulation of radioactivity in the ipsilateral side of the brain after reperfusion.
DMTU treatment significantly attenuated the accumulation of radioactivity in the ipsilateral hemisphere at 1, 5, and 7 h after tMCAO.
However, pre-injection of the TIP-1 specific IgGs dramatically attenuated the accumulation of the fluorophore-labeled peptide within the irradiated tumors (Fig. 2D).
FKBP·cHSF1 activation also attenuates the accumulation of polyQ67-tdTomato into insoluble aggregates.
Similar to the effect of BECN1 knockdown, silencing of ATG7 also markedly attenuated the accumulation of LC3-II (Fig. 2E).
Interestingly, the use of PDGFR inhibitor after injury significantly attenuated the accumulation of αSMA+ myofibroblasts and peritoneal fibrosis.
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