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Likewise, the ERα antagonist fulvestrant has been shown to downregulate AR expression, and therefore attenuate response to AR ligand [ 31].
Our results may indicate that the increased MDM2 levels associated with the SNP309 are insufficient to attenuate response in the BRCA1 mutant breast cells, whereas in the Li Fraumeni cohort studied by Bond et al, there is already loss of one p53 allele.
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Lesions of the anteroventral BNST attenuate responses to acute stress, but potentiate facilitation of the HPA axis by chronic stress (Choi et al. 2008).
This suggests a developmental maturation of the TLR response instead of an attenuated response due to infection.
The apparently attenuated response to α1-adrenergic agonists in vivo may reflect diminished response to these normally synergistic vasopressor pathways.
Nine of these patients (13.8%) were unresponsive and nine patients (13.8%) had attenuated response to second lithium treatment.
Lastly, attenuated response scales such as the 5-point Likert scale can be problematic as they may be subject to floor and ceiling effects (Harris and Hahn 2011).
In addition to an attenuated response to lifestyle programs, AA women also demonstrate high rates of obesity, diabetes, and cardiovascular disease.
Furthermore, this polymorphism tends to show an attenuated response to an HMG-CoA reductase inhibitor in terms of the cholesterol lowering effect.
Furthermore, removal of NeuAc residues from nerve cells reverses MAG-mediated inhibition of neuritogenesis, and neurons from mice lacking the 'NeuAcα3Gal β3GalNAc' terminus have an attenuated response to MAG.
In contrast, mouse amino terminal confers an attenuated response to oxidative stress to the human transporter.
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