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EETs attenuate inflammatory processes, which play a key role in the pathophysiology of cardiovascular diseases [ 91].
Moreover, IL-1β inhibition has been tested to attenuate inflammatory processes in atherosclerosis (33), and future research may be helpful to investigate the potential for comparable approaches in individuals at high risk for DSPN.
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For example, it inhibits cell proliferation, reduces angiogenesis, reduces cell migration and metastasis, and attenuates inflammatory processes [ 23].
Leptin synergizes with IL-1 or interferon-γ to increase NO production in chondrocytes [ 130], and leptin deficiency attenuates inflammatory processes in experimental arthritis [ 131].
Leptin synergizes with IL-1 or interferon-gamma to increase NO production in chondrocytes [ 88], and leptin deficiency attenuates inflammatory processes in experimental arthritis [ 89].
Recent work has suggested ghrelin administration during the acute or "ebb" phase in burned rats improves outcome by increasing growth hormone, inhibiting protein breakdown and attenuating inflammatory processes [ 61- 63].
Recruitment of immune cells to the site of inflammation precedes a cascade of cellular events leading to inflammatory responses, and inhibition of this recruitment can attenuate the inflammatory processes.
Their approach suggested that the respective coating approaches are a possible way to attenuate local inflammatory processes in order to reduce FBR.
These results indicate that stem cells and their progenies are able to attenuate the inflammatory process at the site of injury, contributing to the healing progression.
Therapeutic immunosuppression and novel biological therapies can suppress or attenuate the inflammatory process as long they are applied, but cannot switch off the underlying mechanisms inducing therapy-free remission, that is, cure.
However, the injection of recombinant IL-12 enhances the severity of CIA during the induction phase, but attenuates the inflammatory process when administered in established CIA.
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