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Because of thrombin's multiple roles in coagulation, thrombin inhibitors not only block fibrin formation but also attenuate further thrombin formation and platelet activation [ 5].
Furthermore, once Δψ m decreases below about ∼120 mV, ATP synthesis is no longer possible, and reversal of the ATP synthase will attenuate further decreases.
Subsequent stimulation of membrane-bound adenosine receptors may act as a negative-feedback mechanism to control and curtail the inflammatory response and to attenuate further organ damage.
The action of miRNAs may not to be reflected on the level of their target mRNAs as they are believed to block or attenuate further translation of mRNAs to protein.
Given the high rate of CV mortality in patients with CKD, the necessity of screening patients for vascular calcification, determining which patients are at high risk of CV events and which steps to take to attenuate further progression, is a matter of ongoing debate [ 20].
The above experimental studies indicate that the positive association of OPG with vascular calcification in humans may not be necessarily causative, and it remains unclear whether increased OPG levels promote arteriosclerosis, or merely represent a compensatory mechanism aiming to attenuate further vascular injury [ 16, 44].
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Since LegCo is a mixture of popularly elected delegates and representatives of "functional constituencies" (professional, commercial and other interest groups), its powers already weak are attenuated further by questions over its legitimacy.
Low physiological magnitudes of biomechanical forces prevent phophorylation of TAK1 (TGF-β activating kinase), which in turn inhibits phosphorylation of IKK, resulting in attenuating further downstream NF-κB signaling cascade.
We assessed barrier function of monolayers stretched in the presence of the inhibitors, and found that neither inhibitor had any effect on permeability following 10 minutes of stretch, but after 60 minutes of stretch, both JNK and ERK inhibition significantly attenuated further permeability increases.
Such reduction could decrease the tidal stretch imposed on the lung, potentially attenuating further the ventilator-induced lung injury [ 2].
Weak risks were found also for persistent occasional economic difficulties and decreasing economic difficulties, and they attenuated further after full adjustments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com