The current studies, in conjunction with our recent studies on nitric oxide synthase activity in the kidney, strongly suggest that potassium attenuates development of hypertension by increasing nitric oxide production in Dahl rats.
The results are compatible with the idea that increased lipoprotein formation in cardiac myocytes attenuates development of cardiac dysfunction in fat-fed obese mice.
Like ST2−/− mice [56] and mice treated with a soluble ST2-Fc fusion protein [57], mice treated with a certain anti-ST2 mAb (generated by Amgen) showed attenuated development of collagen-induced arthritis [58].
However, deficiency of XBP-1 markedly attenuated development of disease signs, as it resulted in an increase in autophagy and decreased levels of SOD1 aggregation [ 81].
Compared with wildtype control mice, survival is improved in septic CXCR3-deficient mice and is associated with decreased systemic cytokine production and attenuated development of hypothermia [ 16].
Although McCurdy et al. showed that prepregnancy diet normalization partially attenuated development of fatty liver disease in fetal offspring, there is no evidence regarding the potential beneficial effect of this nutritional intervention on fetal UPR or insulin sensitivity.
Previous studies reported that MMP inhibitor (RP59794) [ 111] or MMP-9 gene knockout [ 112] reduced osteoclast migration, which results in reduction of the resorption process in the growth plate and, as a consequence, attenuated development of bone marrow cavity.
Our data show that RP105-deficient mice exhibit an accelerated onset of more severe arthritis, with an increased cytokine production of T cells and attenuated development of regulatory T cells (Tregs).
We have previously shown that interfering with the function of the neuron-restrictive silencer factor (NRSF/REST), an important transcription factor that influences neuronal phenotype, attenuated development of this disorder.
Inhibition or lack of MIF attenuated development of septic shock [ 3, 6], encephalitis [ 13], autoimmune encephalomyelitis [ 16, 17], rheumatoid arthritis [ 25, 26], colitis [ 27], concanavalin A induced liver injury [ 28], glomerulonephritis [ 29] and atherosclerosis [ 30].
Whole-body deficiency of CCR2 reduced the size of atherosclerotic lesions in both the en face measurement of aortic intima and in tissue sections from the aortic sinus, and attenuated development of AAAs.
