Sentence examples for attenuate cell death from inspiring English sources

In summary, since catalase can only attenuate cell death when m-aconitase is overexpressed, this suggests 1) that the excess H2O2 from m-aconitase inactivation is being released from astrocytes and injuring neighboring neurons and 2) that removal of astrocyte-derived extracellular H2O2 can prevent death.

Inhibition of lysosomal proteases did not attenuate cell death induced by the combined agents.

In contrast to Os, Cl may attenuate cell death due to apoptosis and prevent the impairment of cardiac performance.

The complexity of the apoptotic cascade provides many opportunities, or perhaps more so challenges, for the design of interventions that might attenuate cell death (Fig. 1).

Furthermore, we have shown that brief exposure of human neural precursors to sublethal hypoxia can attenuate cell death induced by injurious events common to ischemic stress.

Recent experimental data suggest that mitochondria undergo fission and MPTP opening in response to acute IRI, and genetic or pharmacological inhibition of mitochondrial fission inhibits MPTP opening and attenuate cell death (Ong et al., 2010).

Overexpression of TRPC1 increased Pb2+-induced cell death, while knockdown of this channel attenuated cell death.

Knockdown of endogenous MCU decreases mitochondrial Ca2+ uptake following histamine stimulation and attenuates cell death induced by oxidative stress in both HeLa cells and CGNs.

Overall, this study strongly suggests that the major function of TG2 in the cell does not involve its transamidating activity and that it attenuates cell death in a transamidating activity independent manner when localized to the nucleus.

A causal link between up-regulation of GPR17 and extent of brain damage was suggested by data showing that inhibition of GPR17 by either pharmacological agents or by an antisense-oligonucleotide strategy markedly attenuated cell death (ibidem).

This study demonstrated that melatonin attenuates cell death in the fetal brain in association with a reduced inflammatory response in the blood and the brain following intrauterine asphyxia in mid-gestation fetal sheep.