The phrase "attenuate binding to" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly in discussions about molecular interactions or pharmacology.
Example: "The new compound was shown to attenuate binding to the receptor, reducing its activity."
Alternatives: "reduce binding to" or "diminish binding to".
The α2-blocking antibody 6F1 attenuated binding to p8 and to CRP, implying a nonspecific effect.
These folding patterns are consistent with the binding affinity of p53 to MDM2 where only the phosphorylation of T18 attenuates binding to MDM2 [ 18].
Interestingly, pre-phosphorylation of a GST-Occ C-terminal domain fusion protein attenuated binding to ZO-2, whereas, binding to ZO-1 was not affected.
This substitution is relevant to PI3K binding because an HRAS-D33I mutant showed attenuated binding to p110α and DIRAS1-I37D showed reduced binding to p110β, even though exchange of this residue did not enable RAS binding to p110β or DIRAS binding to p110α, pointing to additional, G2-box-independent determinants of PI3K isoform specificity.
Typically, we observe that it is the FG residues (pink boxes), but not intervening spacer residues (no boxes), that attenuate upon binding to the transport factor Kap95; however, there are four FG repeats that are minimally attenuated (blue boxes), and a small number of spacer residues that are attenuated (purple boxes).
Nevertheless, competitive ELISA revealed that multimeric VTNC, heat-modified monomeric VTNC, or SMTB 1 44 at high concentrations attenuate Cyr61 binding to immobilized VTNC, while monomeric VTNC was ineffective.
Furthermore, siRNA depletion of Nrf2 abrogated PKCε-induced HO-1 mRNA and protein up-regulation, whereas knockdown of either CREB1 or Nrf2 was able to attenuate Nrf2 binding to the ARE consensus oligonucleotide.
However, similar to some soluble membrane receptors, the soluble PRRT2 may still preserve binding ability to the interactive proteins or ligands and attenuate their binding to the wild-type PRRT2, i.e. dominant negative effect (Celli et al., 1998).
10. 15d-PGJ2 has a possible role, via COX2 up-regulation, in resolution of inflammation (arthritis research & therapy 2011 12 R92) 11. 15d-PGJ2 AP1enuates AP1 binding to DNA and is highly potent to counteract IL01b induced COX2 and INOS expression in human chondrocytes- possibly indicating its action to be mainly independent of PPARg FEBS let 2001, 13 501(13 50130).
Both FLNA2556 2565 and FLNA2561 2570 markedly attenuated [3H]NLX binding to A7 cell membranes and to purified human FLNA (Fig. 4).
