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The inhibition of methyltransferases is currently of high interest, particularly in the areas of microbial infection and cell proliferation, as there have been serious attempts to develop novel anti-microbial agents.
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Moreover, based on this research, we attempted to develop novel biodegradable nanoparticles composed of hydrophobic poly(γ-glutamic acid) (γ-PGA) derivatives (γ-hPGA).
In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization.
In an systematic attempt to develop novel Selective Estrogen Receptor Modulators (SERMs), chiral 1- 4- 2- dialkylamino)ethoxy)phenyl)(2-hydroxynaphthalen-1- 4- 2- dialkylamino4-ols wethoxy phenylbased on an accepted pharmacophore model.
Consequently, numerous researchers have attempted to develop novel nanostructures with these desirable properties [8 12].
"We have not made any changes in our general philosophy of following scientific innovation in an attempt to develop novel, breakthrough medicines to improve and extend people's lives.
Indeed, there has been a large research effort in attempting to develop novel antidepressants targeting the HPA system [ 70], although this is yet to achieve success [ 71].
Furthermore, we will attempt to develop novel inexpensive diagnostic tools, both for human diagnostics as well as for vector monitoring that will enhance an integrated surveillance system.
Understanding this rheostat system, which critically balances the cell fate, will be helpful in rationalizing the modes of cell survival, attempting to develop novel and advanced therapeutic tools.
The ultimate challenge in coming years will be understanding the stem cell 'programme', particularly the control of self-renewal, in an attempt to develop novel, stem cell-directed therapies.
In an attempt to develop novel pathway inhibitors, efforts have also been focused on targeting direct downstream effectors of Cdc42 such as WASp, including the ubiquitously expressed N-WASp.
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