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Furthermore, although cytokines have biological effects on cardiac contractility, extracellular matrix deposition, and apoptosis induction, their increase in remodelling could signify both beneficial attempts of tissue repair and a drive towards tissue injury.
Initial attempts of tissue analyses of QD705 using fluorescence spectroscopy were unsuccessful because of problems related to extraction of QD705 from the tissues and the interference of fluorescence detection by endogenous substances in the tissues.
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Moreover, the granulomata showed proliferation of fibrocytes and increase in the amount of fibrous tissue that was obviously seen in Masson's trichrome (MT -stained sections suggesting that there is an atteMT -stainedue healing.
As mentioned before, several studies in animal models of early OA identified an initial phase of cartilage hypertrophy prior to its degeneration and loss [ 46] and, although the explanation of this phenomenon was not clarified yet, it could be an expression of the inflammation and an attempt of tissue reparation.
The knowledge that the expression of decorin and biglycan by alveolar bone cells, derived from periodontal ligament and bone marrow sources, is reduced in the presence of LPS, confirms that the decorin and biglycan observed in the GCF during these clinical situations derives from the degradation of the matrix, rather than from attempts of the tissue to undergo repair.
In contrast with histochemical and biochemical data, however, the in vivo AF analysis is able to indicate an attempt of liver tissue to counteract oxidative stress.
As in early osteoarthritis it may be an attempt of the tissue to prevent matrix degradation [ 33] and thus, in the case of the photooxidized cartilage actually be a positive sign for viability and repopulation with living cells.
Most attempts to tissue-engineer cartilage have involved seeding of cultured cells into a biological or synthetic scaffold.
In the past, there have been attempts to create 3D images of tissue samples.
First attempts to reduce this loss of tissue focused on changes of implant shapes, implant surfaces, implant position, and abutment design.
Earlier attempts to use the increase of tissue scattering in the retina [ 11] or autofluorescence [ 12] were not successful.
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