In current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality.
Rosenblum and coworkers proposed that evolution of La to attain additional functionality might have included a change in the NLS [4].
In LbL film assembly, tuning extrinsic conditions such as pH or ionic strength can induce two components to form multilayer films when they attain complementary functionality (i.e., cationic/anionic or H-bond donor/H-bond acceptor).
Domains in protein sequences are basic evolutionary units [ 17, 26] that constantly evolve to attain new functionality either by combining with other domains or by completely changing into a new domain.
To attain these functionalities, the software of the system accepts the principles that characterise pervasive system software [14].
When P/F > 1 (i.e. resoles), a more complex situation arises, with formaldehyde never achieving an actual functionality of two while phenol may now attain an actual functionality greater than two.
During translocation and subsequent trafficking, nascent proteins begin to fold, attaining specific conformations that determine protein functionality (1).
Success in architectural design consists in attaining beauty of form in light of functionality or, in Kantian terms, an adherent (non-free) beauty in buildings as defined by realization of their intended goal-state (Critique of the Power of Judgment, 1790).
For instance, Miller and Sim [ 3], who conducted interviews with several EMR users, observed that attaining benefits depends heavily on physicians' use of EMR functionalities.
Through evolution these biological systems have attained a level of functionality that would be impossible to recapitulate with de novo assembly.
In spite of the enormous possibilities presented by macromolecules for the development of advanced materials with increased functionality, the achievement of functionality is often limited by the randomness associated with polymer synthesis and the exponential increase in technical difficulties encountered in attaining a desired degree of complexity in the molecular design.
