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In this phase II trial, the planned sample size was 45 patients, which was calculated by Southwest Oncology Group's two-stage attained design 9 based on an expected clinical complete remission rate of 60% and a threshold of 40%, with an interim one-sided alpha of 0.02 for futility, final alpha of 0.105, and a power of 0.9.
This sample size was calculated using Southwest Oncology Group's two-stage attained design 10 based on an expected %CR of 85% and threshold of 70% in patients with T1 2, and an expected %CR of 65% and threshold of 45% in patients with T3, with a one-sided alpha of 0.05 and a power of 0.9.
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It advocates the use of rigorous physical model for each mass/heat transfer stage to ensure the practical reliability and optimality of the attained designs.
These stages are (i) attaining design standards, (ii) incremental innovations, and (iii) ushering radical innovation.
Due to the substantial reduction of the overall expansion of alumina magnesia castables, the addition of hydratable alumina was pointed out as an interesting alternative to attain designed expansion levels.
This sensor, along with an optimum concentration of inner filling solution (2×10−4 mol L−1 UMEC) and 2 h of soaking time, attained the design objectives.
This exactness verification test works fine in practice, and we will show via a numerical example that exact robust control is indeed attained by designing PTVMSFCs, even for such a problem where the standard memoryless static state-feedback fails.
The results show that concrete with up to 40% replacement level of sand by laterite attained the designed strength of 20 N/mm2, thus indicating the possibility of using laterite as a partial replacement for sand up to this level.
No long-term drift of the Ta2O5 gate films will be attained by designing the ultra-thin layer on the surface of the Ta2O5 films: the low-temperature process and the reduction of impurities in Ta2O5 films.
An empirical study revealed that the presence of visual stimuli of different kinds can affect performance, measured in terms of practicality, originality and creativity scores attained by designs developed by subjects under different conditions.
This study suggests that considerable gains might be attained by designing organized, evidence-based interventions that target improving health literacy among veterans, and especially those with key chronic conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com