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Genomic selection methods have been criticized by researchers who doubt that the number of nonzeros (s) will typically be smaller than a practically attainable sample size (n) [ 19].
The choice of each of these factors impacts on the final sample size, and the skill is in combining realistic values for each of these in order to achieve an attainable sample size.
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In sequencing studies of common diseases and quantitative traits, power to individually test any rare or low frequency variant is typically weak in attainable sample sizes.
We found evidence for rare variants outside the 22q11.2 region perturbing gene networks relevant to idiopathic schizophrenia, for a DGCR8/miRNA-related mechanism, for other noncoding sequence variants, and for a polygenic risk contribution, and predicted that maximal statistical power can be achieved with attainable sample sizes of this genetic model.
Here, statistical power is attainable despite a small sample size: a single patient (or cell line, or tissue, etc).
Given an observed occurrence of the population proportions and the sample size, all attainable draws of the three counts can be enumerated and assigned their respective trinomial probability.
This surrogate primary outcome marker has been chosen as it provides a sample size that is feasible and attainable for a phase II trial to test efficacy.
The target sample size of 200 at T1 is therefore attainable.
Based on 80% eligibility and 50% participation rates, the target sample size of 1000 out of 2400 patients is attainable.
The planned sample size was 100 patients, which was estimated to be a representative number and attainable within our single institution.
The sample size of the BASIC-HHD study of 500 patients was chosen as a realistically attainable cohort size based on feasibility considerations.
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