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Genomic selection methods have been criticized by researchers who doubt that the number of nonzeros (s) will typically be smaller than a practically attainable sample size (n) [ 19].
In sequencing studies of common diseases and quantitative traits, power to individually test any rare or low frequency variant is typically weak in attainable sample sizes.
The choice of each of these factors impacts on the final sample size, and the skill is in combining realistic values for each of these in order to achieve an attainable sample size.
We found evidence for rare variants outside the 22q11.2 region perturbing gene networks relevant to idiopathic schizophrenia, for a DGCR8/miRNA-related mechanism, for other noncoding sequence variants, and for a polygenic risk contribution, and predicted that maximal statistical power can be achieved with attainable sample sizes of this genetic model.
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Here, statistical power is attainable despite a small sample size: a single patient (or cell line, or tissue, etc).
In order to better understand the response to Sr, using an easily attainable and standard biodosimetry sample fluid, we analyzed the global transcriptomic response of blood cells in an in vivo model system.
Inspections of samples disclosed attainable morphologies and also how transitions between morphologies occurred.
SDE concept uses (i) the lowest sampling rate attainable theoretically and (ii) the same universal HW device in every application.
The main difficulty is to cope with the temporal limits introduced by the limited sampling rate attainable by such an architecture.
Given an observed occurrence of the population proportions and the sample size, all attainable draws of the three counts can be enumerated and assigned their respective trinomial probability.
Thus, when large sample sizes are attainable, more complex models involving much more recent demographic events may still be successfully analyzed using the AFS.
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