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Dosage was identical to that in the ATTAIN trial.
In the 6-month ATTAIN trial, patients with an inadequate response to anti-TNF therapy received abatacept or placebo, plus ⩾1 disease-modifying antirheumatic drug.
The ARRIVE study, unlike the ATTAIN trial, included patients who had failed anti-TNF therapy because of lack of efficacy, safety or tolerability reasons alone.
The patient subsequently discontinued from the ATTAIN trial due to cholangiocarcinoma, which was the probable cause of the elevated CRP levels.
Of the 258 and 133 patients randomised and treated with abatacept or placebo, respectively, in the ATTAIN trial, 171 patients treated with abatacept and 75 patients treated with placebo had ESR and CRP measurements available for analysis.
In a similar pattern to the ATTAIN trial, 2 years of treatment with abatacept decreased the proportion of patients with fatigue, pain, and sleep problems (Dougados et al. 2007a).
Similar(49)
Both studies are evaluating the cost-effectiveness of abatacept, using data from the clinical AIM or ATTAIN trials with methotrexate or an unspecified DMARD as comparator, respectively.
A retrospective, post hoc, subgroup analysis of prospectively collected data from the Phase 3 ATTAIN trials of telavancin versus vancomycin for treatment of nosocomial pneumonia was conducted to further investigate the relationship between vancomycin serum trough levels and patient outcome.
The ATTAIN trials were two identical, randomized, double-blind, comparator-controlled, parallel-group, Phase 3 studies (NCT00107952 and NCT00124020) investigating the efficacy and safety of telavancin versus vancomycin for treatment of Gram-positive NP in adult patients [ 10].
The ATTAIN trials were double-blinded studies in which patients were randomized (1 1) to receive either intravenous (IV) telavancin at a dosage of 10mg/kgg every 24 h or vancomycin at a dosage of 1 g IV every 12 h for 7 21 days.
Risk assessments are important under conditions of low risk when estimates are difficult to attain from trials.
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