If the in vitro success of this antiviral validated in this current work can be demonstrated with future in vivo studies, this antiviral technique has the potential to attain clinical relevance by providing a safe and efficacious method of delivering siRNAs to target tissues, including avian epithelium, without inducing cytotoxicity.
In this perspective, studies on hepatic mitochondrial metabolism and functional integrity in thyroid dysfunction attain utmost relevance.
Such retrocopies might attain biological relevance and become evolutionarily stable and, thus, ultimately be overrepresented as other unstable retrocopies are eliminated.
Some of those musicians — the major heroes of jazz, who attained peak relevance in the '60s or '70s — are entering their true late periods.
Although the natural history of DCIS is unknown, autopsy data indicate the existence of a reservoir of DCIS in the population that is never diagnosed and never attains clinical relevance [ 21, 22].
As stated in the 2006 I-PWG publication, this approach 'takes into account that participants may change their minds during the course of the study' while also acknowledging the possibility that genetic markers would have been identified during this time that have attained clinical relevance.
Based on the obtained results, we suggest that retrocopies attained biological relevance and were subject to natural selection following fusion with existing genes or acquisition of new gene elements, although many retrocopies have ultimately been eliminated from the genome during coelacanth evolution.
To attain maximum clinical relevance and acceptability, researchers must conduct clinical trials designed to meet the needs of clinicians and others who are making decisions about patients' care.
METHOD: To attain maximum clinical relevance and acceptability, the Child and Adolescent Psychiatry Trials Network (CAPTN) will transport to pediatric psychiatry the practical clinical trials model widely used in other areas of medicine.
Hence, to attain an optimal feature subset of minimal redundancy and maximal relevance, a heuristic strategy named incremental feature selection [ 31, 32] is adopted for the search of feature subset.
Prior to distribution, the questionnaire was pre-tested for understandability of the questionnaire wording had relevance in the Singapore health care context, and to attain estimates of the amount of time required to complete the questionnaire.
