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‡In the PIAMA study, 'frequent asthma symptoms' are defined as having asthma symptoms and ≥4 attacks of wheeze or ≥4 attacks of dyspnoea in the last 12 months.
Current severe wheeze was defined as those who, according to the written questionnaire, responded positively to all four questions: 1) "How many attacks of wheeze have you had in the past 12 months?".
Severe wheeze included four or more attacks of wheeze, one or more nights per week of wheeze, or wheeze with shortness of breath so severe as to interfere with speech (ISAAC Steering Committee 1998).
Severe asthma symptoms: was considered present if children with current asthma symptoms reported: 4 or more attacks of wheeze, being woken by wheeze at one or more nights per week or wheezing severe enough to limit speech to only one or two words at a time between two breaths.
"Current wheeze" entailed symptoms of wheeze in the preceding 12 months, "current severe wheeze" was four or more attacks of wheeze in the preceding 12 months, and "current dry cough" was dry cough during the night without simultaneous cold or other respiratory infections in the preceding 12 months.
The asthma outcome used throughout our analyses was severe wheezing in the preceding 12 months, defined as at least four attacks of wheeze or at least one episode of speech-limiting wheeze, or sleep disturbance due to wheeze at least once a week, during the preceding 12 months (Lai et al. 2009).
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By contrast, attacks of wheezing had the highest specificity (65.8%), but moderate sensitivity (50.8%).
3.44-fold (95% CI 1.19 9.94) more likely to experience severe attacks of wheezing limiting speech (P = 0.02).
A wide diversity of RV genotypes cause recurrent infections that lead to attacks of wheezing that begin in infancy.
The question on wheeze ever, does not mention attacks of wheezing in order to identify children with persistent symptoms characterised as episodes of attacks [ 42].
Compared to asthmatic children without rhinitis, those with both asthma and rhinitis were: 2.89-fold (95% CI 1.41 5.91) more likely to experience frequent attacks of wheezing (P < 0.01).
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