Sentence examples for attachments to the matrix from inspiring English sources

Our findings indicate that syndecan-1 regulates the affinity state of the α2β1 integrin subunit, which in turn appears to coordinate cell attachments to the matrix that are required for spreading and migration.

This affinity facilitates cell attachment to the matrix and also activates integrin-mediated signaling [ 6].

In contrast, metastatic cancer cells often have weak cell-matrix adhesion, so strengthening their attachment to the matrix facilitates the completion of cell migration cycles.

Since tumor invasiveness is highly dependent on cell adhesion, the strength of cell attachment to the matrix of a culture plate was quantified in an adhesion assay.

Cells maintain adhesion through focal adhesions, which are clusters of integrin receptors that provide strong mechanical points of attachment to the matrix.

They found that surface-exposed EGF promoted cell attachment to the matrix material and increased MSC spreading and survival when compared with media containing solubilized EGF.

Binding of the ligand mediates attachment to the matrix, while phosphorylation of the receptor relays spreading of the cells to the matrix [ 27] through the formation of filopodia, lamellipodia, and stress fibers [ 28].

We believe that this data should clarify why cells targeted to extrude with upregulated survival signaling (P-FAK) do not die if extrusion is blocked since active FAK remains high from prolonged attachment to the matrix.

Data on the location of transcribed elements within structural loops at the supragenic level suggest that attachment to the matrix and transcription is not systematically associated [ 57, 58], though S/MARs are associated with the ends of some DNaseI-sensitive (transcriptionally poised) domains [ 59].

Adherence to extracellular matrix is an intrinsic characteristic of an invasive and metastatic phenotype and migrating cells form transient attachments to the extracellular matrix.

These carriers can further contain therapeutics by: (a) dissolving, absorbing or dispersing throughout the matrix; (b) covalent attachment to the polymer matrix; or (c) encapsulation within the core [119].