Sentence examples for attachment to the matrix from inspiring English sources
This affinity facilitates cell attachment to the matrix and also activates integrin-mediated signaling [ 6].
In contrast, metastatic cancer cells often have weak cell-matrix adhesion, so strengthening their attachment to the matrix facilitates the completion of cell migration cycles.
Cells maintain adhesion through focal adhesions, which are clusters of integrin receptors that provide strong mechanical points of attachment to the matrix.
Since tumor invasiveness is highly dependent on cell adhesion, the strength of cell attachment to the matrix of a culture plate was quantified in an adhesion assay.
They found that surface-exposed EGF promoted cell attachment to the matrix material and increased MSC spreading and survival when compared with media containing solubilized EGF.
We believe that this data should clarify why cells targeted to extrude with upregulated survival signaling (P-FAK) do not die if extrusion is blocked since active FAK remains high from prolonged attachment to the matrix.
Our findings indicate that syndecan-1 regulates the affinity state of the α2β1 integrin subunit, which in turn appears to coordinate cell attachments to the matrix that are required for spreading and migration.
These carriers can further contain therapeutics by: (a) dissolving, absorbing or dispersing throughout the matrix; (b) covalent attachment to the polymer matrix; or (c) encapsulation within the core [119].
Epidermal growth factor (EGF), incorporated with the matrix material, increases cell attachment to the implanted matrix and increases the spreading of mesenchymal stem cells [ 10].
In addition, they indicate that β1-integrin and the extracellular matrix proteins fibronectin and laminin are downregulated, which will also reduce proliferation as attachment to the extracellular matrix is required to maintain the proliferative potential of epithelial cells.
Another type of adhesion that keeps cells in place is their attachment to the extracellular matrix, the network of substances secreted by cells and found between them that helps to provide structure in tissues.
