It is standard engineering practice to attach an estimate of error or uncertainty to a central estimate – to provide only a central estimate can be highly misleading.
Given that a major use of QSAR predictions is in chemoinformatic tabulations used by medicinal chemists and other third parties, it would be good practice to routinely attach some estimate of uncertainty to each prediction.
Different model specifications were compared using the log likelihood ratio index (LLRI) and the preferred MXL (with highest LLRI) was employed to inform the WTP estimates (see Additional file 1); its attached WTP estimates did not change the direction of the CBA findings based on the CL model (see Additional file 2).
Given the importance attached to estimates in global health, we also reflect upon alternative ways in which country estimates can be generated.
A source of bias is attached to estimates of minimal amount of change, simply because it is difficult to judge whether patients who report themselves to be "slightly" or "moderately" improved have had a change that one can consider to be important.
Lot 9 in the Isabell sale is a virtually identical piece from that series, but Sotheby's is playing it safe by attaching an estimate of $60,000 to $80,000.
RM Auctions has consigned the steam-powered Victorian machine to its annual Hershey auction, and the company has attached an estimate ranging from $2 million to $2.5 million.
Subsequently, the amount of cells attached was estimated by measuring the absorbance (OD650) of CV dissolved in 0.5% SDS by the plate reader.
A question of fundamental importance for meta-analysis of heterogeneous multidimensional data studies is how to form a best consensus estimator of common parameters, and what uncertainty to attach to the estimate.
Traditionally, a range of methods is routinely employed, e.g. Nearest Neighbor substitution through to Kriging, but few methods attach a quality estimate to the infilled values.
