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At useful doses, it "became indistinguishable" from a benzodiazepine.
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Taken together, these findings demonstrate that compound H-Arg-15-15C H-Arg-15-15C H-Arg-15-15C H-Arg-15-15Clgesis and anti-inflammatory achannel in vivo at clinically useful doses and sublockerate the tenet that TRPV1 plays an impofTRPV1role in the etiology of chronic inflammatory pain.
Thus, a drug that is effective at the molecular level may not necessarily achieve clinically useful doses in the tumour.
As well as the intravenous form, an oral preparation is being developed that appears to be well tolerated at a therapeutically useful dose [ 8].
It may be difficult to derive useful dose-response relationships from single doses in such cases.
In the available trials, triptans were used at safe doses while still experiencing clinically useful levels of efficacy.
Our main need is to extrapolate downward from observed effects at high doses, using the presumption that the dose-response pattern seen in animals is giving us useful information about the human dose-response pattern and its lower dose range.
Such information would be useful for "dosing" daily steps in clinical practice.
Although systemic chemotherapy at high doses could be useful in this case, intrathecal chemotherapy allows a better distribution throughout the subarachnoid space with less systemic toxicity [ 1].
Clinical experience with doses >100 mg daily is very limited, but data reported to date suggest that TGC may be useful and well-tolerated at higher doses [ 5, 6].
It is considered safe at doses we use for weight".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com