The phrase "at transitions" is correct and usable in written English.
It can be used to refer to moments of change or shifts in context, such as in writing, speaking, or processes.
Example: "The author skillfully highlights the emotional shifts at transitions in the narrative, enhancing the reader's experience."
Alternatives: "during changes" or "at turning points".
Detected p53 mutations were mainly GC to AT transitions at CpG sites.
Of the 26 mutations recovered, nearly all (92%) were GC to AT transitions at CpG sites, supporting previous data with regard to p53 mutations in Barrett's tumours (Gleeson et al, 1995, 1998).
Of these missense mutations, one was a GC → TA transversion, two were AT → GC transitions and 12 were GC → AT transitions, with six occurring at CpG dinucleotides.
Analysis of the p53 exon 5 mutation spectrum in mutation databases for lung cancer reveals frequent GC > AT transitions, several of which occur at non-CpG sequences.
EMS induces new mutations, mostly GC to AT transitions [ 19], once every ~400 kb at random sites of Drosophila genome [ 20].
Point mutations in the serosa layer displayed equal fractions of GC to AT transitions and GC to TA transversions with some 1-base pair deletions (Figure 8).
Sequence analysis of 20 mutant plasmids indicated that the difference in point mutational spectra between the two layers at 19 months of age is entirely due to the increased level of GC to AT transitions in the mucosa.
However, the major mutations found in DEN-induced tumors were GC-AT and AT-GC transitions in the Ha-ras gene in C3H/He mice, 16 AT-GC and GC-AT transitions and GC-TA transversions in the K-ras gene in A/J mice, 17 and AT-GC transitions in the H-ras gene in B6C3F1 mice.
By sequencing two S. typhimurium mutants grown for 5,000 generations, they observed that the mutation spectrum coincides with the expected pattern, where among the 943 identified nucleotide substitutions, 91% were GC-to-TA transversions and 7% were GC-to-AT transitions [ 56].
p53 mutations in this Merseyside population in the UK do not appear to be as common as in other reports for NSCLC and exhibit predominance of GC-->AT transitions preferentially at non-CpG sites, suggesting that other carcinogens in addition to those in tobacco smoke may be involved in NSCLC in the Merseyside area of the UK.
The stoichiometric and irreversible transfer of adducts to internal cysteine residues at position 145 prevents GC→AT transitions or cross-linking induced by mono-functional and bi-functional alkylating agents, respectively.
