Sentence examples for at time of failure from inspiring English sources
At time of failure, NNRTI mt were seen in 23/26 NVP-failing p. and 0/13 primary PI mt in LPV/r failing patients.
Comparison of virological failure and HIVDR mutation rates obtained from different studies must be interpreted with caution, since threshold and duration of ART at time of failure varies.
Since treatment changes can influence drug pressure on previously selected virus variants, we chose instead to evaluate resistance trends according to the antiretroviral drugs taken at time of failure.
The final models were also rerun considering alternative TCDD exposure scenarios including cumulative exposure dose (area under the curve measured in parts per trillion-years) and estimated exposure dose at time of failure or censorship (parts per trillion).
Especially at times of failure or the unsoundness of formal organizational institutions, the exchange relation between superiors and subordinates turns into an alternative mechanism in such formal institutions to manage individual development (Peng and Heath 1996).
Further, the clinical implications of low-abundance drug-resistant variants at time of virologic failure are unknown.
Our study demonstrates that low-abundance HIV DRMs are commonly unrecognized in antiretroviral-experienced subjects at time of virologic failure.
NNRTI mutations were detected in both low and high abundance in subjects who were on NNRTI-containing regimens either at time of virologic failure or in the past.
Plasma samples from 22 antiretroviral-experienced subjects collected at time of virologic failure (viral load 1380 to 304,000 copies/mL) were obtained from a specimen bank (from 2004 2007).
NNRTI mutations are known to minimally impact viral fitness, and this was observed in our study, in that the majority of subjects (73%) with high-abundance NNRTI mutations were not on NNRTI-containing regimens at time of virologic failure.
Our study using a new ultra-deep sequencing method provides additional evidence that the burden of resistance in treatment-experienced subjects at time of virologic failure is greater than that reflected by standard HIV genotyping.
